Rare Diseases and Orphan Drugs shows that much of what we now know about common diseases has been achieved by studying rare diseases. It proposes that future advances in the prevention, diagnosis, and treatment of common diseases will come as a consequence of our accelerating progress in the field of rare diseases. Understanding the complex steps in the development of common diseases, such as cancer, cardiovascular disease, and metabolic diseases, has proven a difficult problem.

Rare diseases...

We constantly hear cries from politicians for teachers to have high expectations. But what this means in practical terms is never spelled out. Simply deciding that as a teacher you will expect all your students to achieve more than other classes you have taught in the same school, is not going to translate automatically into enhanced achievement for students.

Becoming a High Expectation Teacher is a book that every education student, training or practising teacher, should read. It details the...

Peter Hall’s seminal Cities of Tomorrow remains an unrivalled account of the history of planning in theory and practice, as well as of the social and economic problems and opportunities that gave rise to it. Now comprehensively revised, the fourth edition offers a perceptive, critical, and global history of urban planning and design throughout the twentieth-century and beyond. A revised and updated edition of this classic text from one of the most notable figures in the field of urban plann...

Using Political Ideas is a unique blend of political philosophy, political theory and history of political thought. It combines a critique of the major ideologies of recent and contemporary society with an analysis of the ideas that form the very stuff of political debate.

Nursing Diagnoses: Definitions and Classification is the definitive guide to nursing diagnoses, as reviewed and approved by NANDA-I. The 2015-2017 edition of the classic and internationally recognised text has been rigorously updated and revised, and now provides more linguistically congruent diagnoses as a result of the Diagnostic Development Committee's attentiveness to understanding the translation of the diagnostic label, definition, defining characteristics, related factors, and risk fac...

This new edition made the textbook the first discrete mathematics textbook to be revised in order to meet the proposed new ACM/IEEE standards of the course. It features new material, including new sections on probability, coding theory, matrices and order of magnitude.

In the twentieth century, avant-garde movements have pushed the concept of art far beyond its traditional boundaries. In this dynamical process of constant renewal the prestige of thinking about art as a legitimizing practice has come to the fore. So it is hardly surprising that the past decades have been characterized by a revival or even breakthrough of philosophy of art as a discipline.

However, the majority of books on aesthetics fail to combine a systematical philosophical discourse with...

In light of the rapidly growing number of people studying Arabic--in academia, governments, NGOs, and business--Media Arabic is a unique and timely learning tool for anyone looking to access news information from this important global region firsthand. Media Arabic introduces the language of the newspapers, magazines, and internet news sites to intermediate and advanced level students of Modern Standard Arabic. Using this textbook, students will be able to master core vocabulary and structure...

Doing Bayesian Data Analysis: A Tutorial with R, JAGS, and Stan, Second Edition provides an accessible approach for conducting Bayesian data analysis, as material is explained clearly with concrete examples. Included are step-by-step instructions on how to carry out Bayesian data analyses in the popular and free software R and WinBugs, as well as new programs in JAGS and Stan. The new programs are designed to be much easier to use than the scripts in the first edition.

In particular, there ar...

Put Predictive Analytics into ActionLearn the basics of Predictive Analysis and Data Mining through an easy to understand conceptual framework and immediately practice the concepts learned using the open source RapidMiner tool. Whether you are brand new to Data Mining or working on your tenth project, this book will show you how to analyze data, uncover hidden patterns and relationships to aid important decisions and predictions. Data Mining has become an essential tool for any enterprise tha...