Harvard professor Robert Langdon receives an urgent late-night phone call while on business in Paris: the elderly curator of the Louvre has been brutally murdered inside the museum. Alongside the body, police have found a series of baffling codes.

CERN Institute, Switzerland: a world-renowned scientist is found brutally murdered with a mysterious symbol seared onto his chest. The Vatican, Rome: the College of Cardinals assembles to elect a new pope. Somewhere beneath them, an unstoppable bomb of terrifying power relentlessly counts down to oblivion.

Florence: Harvard symbologist Robert Langdon awakes in a hospital bed with no recollection of where he is or how he got there. Nor can he explain the origin of the macabre object that is found hidden in his belongings. A threat to his life will propel him and a young doctor, Sienna Brooks, into a breakneck chase across the city.